CTCAE Grade 4 Upper Extremity Soft Tissue Necrosis Adverse Event

Life-threatening consequences; major invasive intervention indicated (e.g., tissue reconstruction, flap, or grafting) (NCI Thesaurus/CTCAE)

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CTCAE Grade 4 Upper Extremity Muscle Weakness Not Due to Neuropathy

CTCAE Grade 4 Upper Extremity Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Upper Extremity Function

Disabling; no function of affected limb

CTCAE Grade 4 Upper Extremity Artery Intra-Operative Injury

Life threatening consequences; disabling

CTCAE Grade 4 Upper Extremity Artery Injury

Life-threatening; disabling; evidence of end organ damage (e.g., stroke, MI, organ or limb loss)

CTCAE Grade 4 Upper Airway NOS Intra-Operative Injury

Life threatening consequences; disabling