CTCAE Grade 4 Vas Deferens Leak

Life-threatening consequences; major urgent intervention indicated

Life-threatening; disabling; intervention (e.g., valve replacement, valvuloplasty) indicated

Ulceration and operative intervention indicated

Tissue necrosis; significant spontaneous bleeding; life-threatening consequences

Life-threatening consequences; organ failure or operative intervention requiring organ resection indicated

Life-threatening consequences or organ failure; operative intervention requiring organ resection indicated