CTCAE Grade 4 Vein NOS Intra-Operative Injury

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

Life-threatening consequences (e.g., septic shock, hypotension, acidosis, necrosis)

Ischemic changes; amputation indicated

Life-threatening consequences; organ failure or operative intervention requiring organ resection indicated