CTCF Pathway

CTCF is central to signaling pathways in immature B cells elicited by cross-linking the Ig BCR and stimulation with TGF. Both stimuli result in induction of cell cycle arrest and apoptosis. BCR ligation stimulates a transient induction of MYC that leads to high level CTCF expression and feedback suppression of MYC transcription. BCR ligation also activates PTEN opposing PI3K activation of MYC. Pharmacologic inactivation of PI3K or mTOR/FRAP results in suppression of S6K resulting in activation of CTCF and suppression of MYC. CTCF activation induces transcriptional activation of p19ARF, with its downstream consequences, and of p27. Growth arrest is occasioned by co-expression of p21 and p27 and inhibition of MYC. CTCF, is a multivalent DNA-sequence binder whose specificity is mediated by different sets of zinc finger (ZF) proteins. (NCI Thesaurus/BIOCARTA)

YOU MAY ALSO LIKE

CTCF Gene

This gene is involved in epigenetic control of gene expression.

CTCAE Grade 5 Wound Infection with Unknown Absolute Neutrophil Count

CTCAE Grade 5 Wound Infection with Normal Absolute Neutrophil Count or Grade 1 or 2 Neutrophils

CTCAE Grade 5 Wound Infection Documented Clinically or Microbiologically with Grade 3 or 4 Neutrophils

CTCAE Grade 5 Wolff-Parkinson-White Syndrome

CTCAE Grade 5 Whole Body and Generalized Muscle Weakness Not Due to Neuropathy