| Health / Medical Topics |
CYLD wt Allele
Human CYLD wild-type allele is located in the vicinity of 16q12.1 and is approximately 60 kb in length. This allele, which encodes ubiquitin carboxyl-terminal hydrolase CYLD protein, plays a role in the regulation of both protein ubiquitination and the cell cycle. Mutation of the gene is associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome and may be associated with many types of cancer. (NCI Thesaurus)
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