Health / Medical Topics |
CYP2C9*18 Allele
Human CYP2C9*18 allele is located within 10q24 and is approximately 33 kb in length. This allele, a variant form of the CYP2C9 wild-type allele, encodes cytochrome P450 2C9*18 protein. The CYP2C9*18 allele exhibits a clinically-relevant SNP (c.1190A>C) in exon 8 that results in a D397A coding change. This alteration in protein sequence decreases the in vivo enzymatic activity of the cytochrome P450 2C9*18 protein. (NCI Thesaurus)
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This gene is involved in the oxidation of drugs, xenobiotics, fatty acids and steroids.