CYP2D6*41 Allele

Human CYP2D6*41 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*41 protein. The CYP2D6*41 allele exhibits clinically-relevant SNPs (g.2850C>T; g.4180G>C) in exons 6 and 9 that result in R296C and S486T coding changes. These alterations in protein sequence decrease the enzymatic activity of the cytochrome P450 2D6*41 protein. (NCI Thesaurus)

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