Cytokine-Cytokine Receptor Signaling Pathway

Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. (NCI Thesaurus/KEGG)

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Cytokine Suppression

Any therapeutic or preventive precedure that involves inhibition of the production or activity of a cytokine, and results in the inhibition of…

Cytokine Signaling Process

Any process which promotes expression of cytokine proteins, their subsequent secretion, binding to their cognate receptors or intracellular signaling, and results in…

Cytokine Signaling

Any environment-to-cell cummunication that involves cytokines. This process is involved in immune function.

Cytokine Release Syndrome

A syndrome that occurs after therapeutic infusion of antibodies into the blood and is characterized by nausea, headache, tachycardia, hypotension, rash, and…

Cytokine Receptor-Like Factor 2

Cytokine receptor-like factor 2 (371 aa, ~42 kDa) is encoded by the human CRLF2 gene. This protein is involved in the mediation…

Cytokine Receptor-Like Factor 1

Cytokine receptor-like factor 1 (422 aa, ~46 kDa) is encoded by the human CRLF1 gene. This protein may be involved in both…