Library / English Dictionary

CYTOTOXIC

Pronunciation (US):

(GB):

 I. (adjective) 

Sense 1

Meaning:

Of or relating to substances that are toxic to cells

Classified under:

Relational adjectives (pertainyms)

Pertainym:

cytotoxin (any substance that has a toxic effect on cells)

Derivation:

cytotoxin (any substance that has a toxic effect on cells)

Credits

 Context examples: 

Upon administration, the MELITAC 12.1 peptide vaccine may stimulate the host immune system to mount a cytotoxic T-cell response against tumor cells expressing the melanoma peptide antigens, resulting in tumor cell lysis.

(MELITAC 12.1 Peptide Vaccine, NCI Thesaurus)

Vaccination with this agent may stimulate a host cytotoxic T-cell response against tumor cells expressing melanoma-associated antigens, resulting in tumor cell lysis.

(Melanoma Helper Peptide Vaccine, NCI Thesaurus)

Although the exact mechanism of the depigmenting effects of mequinol remains unclear, it may exert its effect by oxidation of tyrosinase to cytotoxic products in melanocytes.

(Mequinol, NCI Thesaurus)

In addition, this cancer-cell based vaccine may induce a cytotoxic T lymphocyte (CTL) response against prostate specific tumor associated antigens, resulting in an immune-mediated prostate cancer cell death.

(AdRTVP-1-Transduced Prostate Cancer Cell-Based Vaccine, NCI Thesaurus)

This agent reduces total levels of XIAP in tumor cells, working synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis.

(AEG35156, NCI Thesaurus)

Adenovirus B7-1 is used as a component in antineoplastic vaccines to elicit a cytotoxic T-cell response.

(Adenovirus B7-1, NCI Thesaurus)

PADRE is a helper T-lymphocyte epitope that is able to augment the magnitude and duration of the cytotoxic T-lymphocyte (CTL) response.

(Adenovirus 5-Human Guanylyl Cyclase C-PADRE Vaccine, NCI Thesaurus)

When conjugated with a radioactive isotope, Lym-1 monoclonal antibody selectively transports the cytotoxic radioisotope to HLA-Dr10-expressing tumor cells, thereby sparing healthy B-cells and normal tissues.

(Monoclonal Antibody Lym-1, NCI Thesaurus)

A cell that acts in a similar manner to a cytotoxic T cell and must be activated like a cytotoxic T cell.

(Activated Natural Killer Cell, NCI Thesaurus)

There is no history of prior cytotoxic therapy for an unrelated disorder, and there is absence of the cytogenetic abnormalities that are present in acute myeloid leukemia with recurrent genetic abnormalities.

(Acute Myeloid Leukemia with Myelodysplasia-Related Changes, NCI Thesaurus)