| Health / Medical Topics |
D4-GDI Signaling Pathway
D4-GDP dissociation inhibitor (D4-GDI) is a negative regulator of the ras related Rho Family of GTPases. Since the rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kDa mature form of D4-GDI to give a 5 kDa and 23 kDa size fragment. The 23 kDa fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-Terminal kinase, a regulator of apoptosis, may be one of the mechanisms. (NCI Thesaurus/BIOCARTA)
YOU MAY ALSO LIKE
A dinucleotide repeat on chromosome 2 that serves as a marker for microsatellite instability in colorectal cancers.
A dinucleotide repeat on chromosome 17 that serves as a marker for microsatellite instability in colorectal cancers.
The H4 gene is found fused to the RET Gene in papillary thyroid carcinoma and to platelet-derived growth factor receptor betaR in…
A recombinant, chimeric protein derived from a melanoma antigenic epitope (MAGE-3) and recognized by specific cytotoxic T lymphocytes. MAGE-3, a human…
A procedure to remove tissue from the cervical canal or the inner lining of the uterus. The cervix is dilated (made larger)…
A non-essential amino acid and dextro isomer of serine with antipsychotic activity. D-serine is a selective full agonist at the glycine site…
