| Health / Medical Topics |
DBA/2 Mouse
Derived from crosses made by Little in 1929-1930 between DBA progenitors. The DBA/2 mouse has a d H2 haplotype and carries the Cdh23ahl mutation that results in a progressive hearing loss beginning at 3-4 weeks of age and severe hearing loss after 3 months of age. Alleles GpnmbR150X and Tyrp1isa contribute to an eye phenotype that closely resembles human hereditary glaucoma. The DBA/2 mouse strain shows severe intolerance to alcohol and morphine and is naturally CD94 deficient. (NCI Thesaurus)
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