DBL Oncoprotein

Human MCF2 Oncoprotein is a product of a mutated variant (Oncogene MCF2) of widely expressed MCF2 Gene, which encodes 4 alternative variants of 66-kDa MCF2 (DBL) p66 Protein, a cytoplasmic and membrane phosphoserine guanine nucleotide exchange factor that modulates the activity of small RHO GTPases by promoting conversion from GDP- to GTP-bound form. p66 contains a CRAL-TRIO domain, a DH domain, a PH domain and a spectrin repeat; the DH domain catalyzes GDP-GTP exchange. Five-prime recombinations of MCF2 delete N-terminal codons, producing activated oncogenic variant; the upstream replacing sequence, URS, is derived from D15S93 at 15q15-q23. MCF2 Oncoprotein disrupts normal cell function. (NCI Thesaurus)

YOU MAY ALSO LIKE

DBF4 wt Allele

Human DBF4 wild-type allele is located in the vicinity of 7q21.3 and is approximately 33 kb in length. This allele, which encodes…

DBF4 Gene

This gene is involved in DNA replication, protein binding and cell cycle control.

DBE

A procedure used to look at the inside of the small intestine. A special instrument made up of two tubes (one inside…

DBC1 wt Allele

Human DBC1 wild-type allele is located within 9q32-q33 and is approximately 203 kb in length. This allele, which encodes deleted in bladder…

DBC1 Gene

This gene plays a role in receptor-mediated signal transduction.

DBA/2 Mouse

Derived from crosses made by Little in 1929-1930 between DBA progenitors. The DBA/2 mouse has a d H2 haplotype and carries the…