Library / English Dictionary

DE NOVO

Pronunciation (US):

(GB):

 I. (adverb) 

Sense 1

Meaning:

From the beginning

Classified under:

Adverbs

Domain category:

Latin (any dialect of the language of ancient Rome)

Credits

 Context examples: 

A purine derivative with antineoplastic and anti-angiogenic properties. 6-methylmercaptopurine riboside (6-MMPR) inhibits amidophosphoribosyltransferase, the first committed step in de novo purine synthesis, and inhibits fibroblast growth factor-2 (FGF2)-induced cell proliferation.

(Methylmercaptopurine Riboside, NCI Thesaurus)

It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy.

(Myelodysplastic syndrome, NCI Thesaurus/WHO)

A newly discovered, distinct gene alteration; NOT the same as new or de novo mutation.

(Novel Mutation, NCI Dictionary)

The majority of the cases arise de novo, however malignant transformation from a pre-existing pilomatricoma has been reported.

(Pilomatrical Carcinoma, NCI Thesaurus)

Relative to other cell types, lypmocytes are highly dependent on salvage and de novo synthesis of guanine nucleotides, thus making these cells prone to MPA cytotoxicity.

(Mycophenolate Sodium, NCI Thesaurus)

MPA displays high lymphocyte specificity and cytotoxicity due to the higher dependence of activated lymphocytes on both salvage and de novo synthesis of guanine nucleotides relative to other cell types.

(Mycophenolate mofetil, NCI Thesaurus)

As an immunosuppressive agent in vivo, the active metabolite mycophenolate reversibly inhibits inosine 5'-monophosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanine nucleotides, thereby retarding T-cell and B-cell proliferation.

(Mycophenolate, NCI Thesaurus)

This fusion is associated with both with de novo and therapy-related acute myeloid leukemia and myelodysplastic syndrome.

(DDX10/NUP98 Fusion Gene, NCI Thesaurus)

This allele, which encodes dihydrofolate reductase protein, plays a role in the de novo synthesis of glycine, purines and thymidylic acid.

(DHFR wt Allele, NCI Thesaurus)

AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis.

(AVN944, NCI Thesaurus)