| Health / Medical Topics |
Delapril Hydrochloride
The hydrochloride salt of delapril, a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, delapril is converted to two active metabolites, delapril diacid and 5-hydroxy delapril diacid, which competitively bind to and inhibit ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Delapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. (NCI Thesaurus)
YOU MAY ALSO LIKE
A lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, delapril is converted to two active metabolites, delapril diacid…
An orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Delanzomib represses…
Issue associated with peeling of composite materials. Occurs when layers are separated as a result of continuous stress or impact. Results in…
A fusion protein encoded by the DEK/NUP214 fusion gene. This protein is comprised of the majority of protein DEK followed by 2/3…
A fusion gene that results from a chromosomal translocation t(6;9)(p23;q34) which fuses almost the entire DEK gene with the 5' side of…
Human DEK wild-type allele is located within 6p23 and is approximately 40 kb in length. This allele, which encodes protein DEK, plays…
