Depudecin

Depudecin is a fungal metabolite that reverts the rounded phenotype of NIH 3T3 fibroblasts transformed with v-ras and v-src oncogenes to the flattened phenotype of the non-transformed parental cells. The mechanism of de-transformation induced by this agent had not been determined. However, depudecin has been demonstrated to inhibit histone deacetylase (HDAC) activity effectively both in vivo and in vitro. (NCI Thesaurus)

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The extent downward or inward; the perpendicular measurement from the surface downward to determine deepness.

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A muscle that lowers the bottom lip originating at the mandible and inserting at the skin of the lip.