Deslorelin

Pronunciation

Definition 1

A substance being studied in the treatment of cancer as a way to block sex hormones made by the ovaries or testicles. It is a type of gonadotropin-releasing hormone analog. (NCI Dictionary)

Definition 2

A synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. (NCI Thesaurus)

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