Di-dgA-RFB4 Immunotoxin

Definition 1

An immunotoxin of monoclonal antibody (MoAb) RFB4 covalently linked to two deglycosylated ricin toxin A-chain (Di-dgA). This agent can be extracted from castor beans. MoAb RFB4 recognizes CD22 antigen, a B-cell adhesion protein expressed on malignant cells in about 70 percent of non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Ricin toxin A-chain, a potent protein synthesis inhibitor, was deglycosylated and was used in this immunoconjugate to avoid hepatic entrapment. This Di-dgA conjugated MoAb RFB4 delivers 7 fold more cytotoxicity than the single dgA immunotoxin against CD22-positive malignant cells. (NCI Thesaurus)

Definition 2

An anticancer drug that is a combination of a monoclonal antibody (RFB4) and an immunotoxin (dgA). (NCI Dictionary)

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