| Health / Medical Topics |
Diflorasone
A synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. The receptor complex subsequently translocates to the nucleus and activates or represses genes by interacting with short, palindromic DNA sequences called glucocorticoid response element (GRE). Gene activation leads to the exertion of anti-inflammatory effects, e.g. upregulation of IkappaB, while gene repression inhibits production of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-2 and IL-6, thereby preventing activation of cytotoxic T-lymphocytes. (NCI Thesaurus)
YOU MAY ALSO LIKE
A diffusion MRI technique in which diffusion-sensitizing gradients are applied to the imaging sequence.
MRI method that measure the diffusion of water in the tissue, rather than the content of water as measured in conventional…
A solid, semi-solid, solution or suspension covered with an outer permeable polymeric membrane designed to release active and/or inert ingredient(s) at a…
A property of tissues such that a substance shows variable rates of diffusion in different spatial dimensions.
The movement of chemical species under the influence of a concentration difference and as a result of random thermal agitation. The species…
An adenocarcinoma characterized by the presence of a diffuse cellular infiltrate which is composed of poorly cohesive cells with minimal or no…
