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DISRUPTION
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An act of delaying or interrupting the continuity
Example:
there was a gap in his account
Synonyms:
break; disruption; gap; interruption
Classified under:
Nouns denoting acts or actions
Hypernyms ("disruption" is a kind of...):
delay; holdup (the act of delaying; inactivity resulting in something being put off until a later time)
Hyponyms (each of the following is a kind of "disruption"):
cut-in; insert ((film) a still picture that is introduced and that interrupts the action of a film)
cut-in; insert ((broadcasting) a local announcement inserted into a network program)
interjection; interpellation; interpolation; interposition (the action of interjecting or interposing an action or remark that interrupts)
abruption; breaking off (an instance of sudden interruption)
barracking; heckling (shouting to interrupt a speech with which you disagree)
Derivation:
disrupt (interfere in someone else's activity)
disrupt (make a break in)
Sense 2
Meaning:
The act of causing disorder
Synonyms:
disruption; perturbation
Classified under:
Nouns denoting acts or actions
Hypernyms ("disruption" is a kind of...):
disturbance (the act of disturbing something or someone; setting something in motion)
Hyponyms (each of the following is a kind of "disruption"):
breakdown; dislocation (the act of disrupting an established order so it fails to continue)
surprisal; surprise (the act of surprising someone)
Derivation:
disrupt (throw into disorder)
Sense 3
Meaning:
An event that results in a displacement or discontinuity
Synonyms:
dislocation; disruption
Classified under:
Hypernyms ("disruption" is a kind of...):
break; interruption (some abrupt occurrence that interrupts an ongoing activity)
Sense 4
Meaning:
A disorderly outburst or tumult
Example:
they were amazed by the furious disturbance they had caused
Synonyms:
commotion; disruption; disturbance; flutter; hoo-ha; hoo-hah; hurly burly; kerfuffle; to-do
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("disruption" is a kind of...):
disorder (a disturbance of the peace or of public order)
Hyponyms (each of the following is a kind of "disruption"):
convulsion; turmoil; upheaval (a violent disturbance)
earthquake (a disturbance that is extremely disruptive)
incident (a public disturbance)
splash; stir (a prominent or sensational but short-lived news event)
storm; tempest (a violent commotion or disturbance)
storm center; storm centre (a center of trouble or disturbance)
garboil; tumult; tumultuousness; uproar (a state of commotion and noise and confusion)
Context examples:
The inhibition leads to disruption of ALK- and FAK-mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK- and FAK-overexpressing tumor cells.
(ALK-FAK Inhibitor CEP-37440, NCI Thesaurus)
Like vinblastine, anhydrovinblastine targets and binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and causing tumor cell cycle arrest in the M phase.
(Anhydrovinblastine, NCI Thesaurus)
Any apoptotic process triggered by inadequate or inappropriate adherence to substrate, such as may occur after disruption of the interactions between normal epithelial cells and the extracellular matrix.
(Anoikis, NCI Thesaurus)
Mutations in the gene have been associated with disruption of the retinal pigment epithelium phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa.
(MERTK wt Allele, NCI Thesaurus)
Disruptions in mitotic recombination may result in predisposition to cancers.
(Mitotic Recombination, NCI Thesaurus)
Binds to and promotes degradation of p53 protein resulting in disruption of cell cycle regulation.
(Papillomavirus Transforming Protein E6, NCI Thesaurus)
A disorder characterized by tearing or disruption of the ovarian tissue.
(Ovarian Rupture, NCI Thesaurus/CTCAE)
Complexes with and inactivates Rb protein resulting in disruption of cell cycle regulation.
(Papillomavirus Transforming Protein E7, NCI Thesaurus)
A group of sleep disorders causing disruption of sleep.
(Parasomnia, NCI Thesaurus)
Although the exact mechanism of action of pipobroman has yet to be fully elucidated, this agent appears to act by alkylating DNA, leading to disruption of DNA replication and eventually cell death.
(Pipobroman, NCI Thesaurus)
