| Health / Medical Topics |
Distamycin Antineoplastic Antibiotic
An antineoplastic antibiotic isolated from the bacterium Streptomyces distallicus. Distamycin antibiotics bind to the minor groove of DNA, preferentially to adenine-thymine (A-T) rich sequences, thereby inhibiting DNA replication and RNA transcription. In addition to their antitumor effects, these agents possess antiviral and antiprotozoal activities. (NCI Thesaurus)
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