DNA Intrastrand Crosslinking

DNA Interstrand Crosslinking involves the formation of a covalent bond between two bases on different DNA strand.

DNA interstrand cross-links (ICLs) are very toxic to dividing cells, because they induce mutations, chromosomal rearrangements and cell death. A number of…

A liposomal formulation of the 24-mer oligonucleotide PNT100, with potential antineoplastic activity. PNT2258 targets and complements to untranscribed DNA sequence upstream of…

DNA Intercalation involves insertion by covalent linkage of a molecule into the double-stranded deoxyribonucleotide polymer between the internal purine and pyrimidine base…

Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore…

Any DNA sequence rearrangement in which double-stranded DNA from a donor molecule is incorporated into host DNA by the action of an…