Health / Medical Topics

    DNA Maintenance

    DNA Maintenance involves cellular mechanisms that maintain DNA integrity. In many organisms, maintenance of DNA integrity requires not only faithful DNA replication, but also DNA repair and recombination. (NCI Thesaurus)




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    The joining together of two or more nucleic acid molecules by the action of ligase
    DNA ligase 4 (911 aa, ~104 kDa) is encoded by the human LIG4 gene. This protein plays a role in non-homologous end…
    DNA ligase 1 (919 aa, ~102 kDa) is encoded by the human LIG1 gene. This protein plays a role in DNA replication…
    A family of enzymes that catalyze the formation of phosphodiester bonds to repair broken strands of DNA.
    A collection of DNA molecules that have been cloned in vectors.
    DNA Intrastrand Crosslinking involves the formation of a covalent bond between two bases on the same DNA strand.

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