| Health / Medical Topics |
DNA Methyltransferase Inhibitor SGI-110
A dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation, and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra and intracellularly, leading to more prolonged exposures to decitabine. (NCI Thesaurus)
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DNA Methylation Inhibition involves interference with, or restraint of, the process by which methyl groups are added to genomic DNA nucleotides. …
The process by which methyl groups are added to nucleotides in genomic DNA.
An enzyme (a protein that speeds up chemical reactions in the body) that attaches methyl groups to DNA. A methyl group is…
