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DOPAMINE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A monoamine neurotransmitter found in the brain and essential for the normal functioning of the central nervous system; as a drug (trade names Dopastat and Intropin) it is used to treat shock and hypotension
Synonyms:
Classified under:
Hypernyms ("dopamine" is a kind of...):
monoamine neurotransmitter (a monoamine that is functionally important in neural transmission)
Context examples:
Aripiprazole has partial agonistic activity at dopamine D2 receptors and serotonin 5-HT1A receptors, as well as potent antagonistic activity on serotonin 5-HT2A receptors.
(Aripiprazole, NCI Thesaurus)
NM-MRI signal was found to be a marker of dopamine function in people with schizophrenia and an indicator of the severity of psychotic symptoms in people with this mental illness.
(Neuromelanin-sensitive MRI identified as a potential biomarker for psychosis, National Institutes of Health)
Methamphetamine acts by both facilitating the release of catecholamines, particularly noradrenaline, dopamine and serotonin, from nerve terminals in the brain and by inhibiting their uptake.
(Methamphetamine, NCI Thesaurus)
Methamphetamine hydrochloride acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from nerve terminals in the brain and inhibits their uptake.
(Methamphetamine Hydrochloride, NCI Thesaurus)
Pergolide mesylate binds to and activates dopamine receptor subtypes D1 and D2, resulting in prolactin secretion inhibition, transient increase in serum concentration of growth hormone, and decrease in serum concentration of luteinizing hormone.
(Pergolide Mesylate, NCI Thesaurus)
A phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
(Perphenazine, NCI Thesaurus)
Decrease in the amount of soluble alpha-synuclein tends to increase free cytoplasmic dopamine and the formation of reactive oxygen species (ROS).
(Parkinson's Disease Pathway KEGG, NCI Thesaurus/KEGG)
It happens when nerve cells in the brain don't produce enough of a brain chemical called dopamine.
(Parkinson's Disease, NIH: National Institute of Neurological Disorders and Stroke)
Modafinil appears to inhibit dopamine reuptake, resulting in an increase in extracellular dopamine.
(Modafinil, NCI Thesaurus)
The mechanism of action through which nefopam exerts its analgesic effects is, as of yet, largely unknown but may involve inhibition of serotonin, dopamine and noradrenaline reuptake.
(Nefopam Hydrochloride, NCI Thesaurus)
