Drug Metabolism

A series of chemical modifications of a drug compound by enzymatic activity that make the substrate (drug) more water soluble to allow its clearance from the body. Drug metabolism occurs in two phases: Phase I (biotransformation) involves oxidation, hydroxylation reduction, and hydrolysis. Phase II (conjugation) involves synthesis and conjugation. (NCI Thesaurus)

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An indication that a medication schedule was modified by temporarily terminating a prescribed regimen of medication.

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Methemoglobinemia that is caused by exposure to certain drugs (xylocaine and benzene).