Drug tolerance

Pronunciation

Definition 1

A condition that occurs when the body gets used to a medicine so that either more medicine is needed or different medicine is needed. (NCI Dictionary)

Definition 2

Drug tolerance - a reduction in the sensitivity to a drug following its repeated administration, in which increased doses are required to produce the same magnitude of effect previously produced by a smaller dose. This increase in dose may be necessitated by changes in the metabolism of the drug, or a cellular, physiological or behavioral adaptation to the effects of the drug. (NCI Thesaurus)

Definition 3

Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL. (NLM, Medical Subject Headings)

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