| Health / Medical Topics |
DUX4 wt Allele
Human DUX4 wild-type allele is located in the vicinity of 4q35 and is approximately 2 kb in length. This allele, which encodes double homeobox protein 4, is involved in the modulation of transcription. Mutation of the gene is associated with facioscapulohumeral muscular dystrophy and a chromosomal translocation t(4;19)(q35;q13) of this gene and the CIC gene is associated with soft tissue sarcoma. (NCI Thesaurus)
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This gene plays a role in transcriptional regulation.
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