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E-Selectin
Definition 1
Cell adhesion molecule and CD antigen that mediates neutrophil, monocyte, and memory T-cell adhesion to cytokine-activated endothelial cells. E-selectin recognizes sialylated carbohydrate groups related to the Lewis X or Lewis A family. (NCI Thesaurus)
Definition 2
E-Selectin is expressed by cytokine-stimulated endothelial cells and is thought responsible for accumulation of neutrophils, monocytes, and memory T-cells at sites of inflammation. Neutrophil accumulation at sites of inflammation is mediated by cell adhesion molecules including the CD18 integrins on leukocytes and the selectins (P- and E-selectin on endothelium and L-selectin on leukocytes). E-Selectin exhibits homologous structural features to L-selectin, including lectin- and EGF-like domains followed by SCR domains. E-Selectin recognizes Lewis X family- or Lewis A family-related sialylated carbohydrate groups. (from OMIM 131210 and NCI) (NCI Thesaurus)
Definition 3
Encoded by human SELE Gene (Selectin Family), 610-aa 66.5-kD E-Selectin precursor is a cytokine-induced endothelia type I membrane protein with features homologous to LYAM1: a C-type lectin domain, an EGF-like domain, six cysteine-containing SCR (sushi) domains. Likely having an evolutionary history with LYAM1, GRMP, and complement binding proteins, ELAM1 mediates cell adhesion binding of endothelial cells to leukocytes, such as Neutrophils, during inflammatory responses. ELAM1 recognizes glycolipid polylactosamine derivatives and may be involved in the pathogenesis of atherosclerosis. An aa149 polymorphism is associated with higher risk of coronary artery disease and ELAM1 is a diagnostic indicator of glaucoma. (from LocusLink, Swiss-Prot, OMIM, and NCI) (NCI Thesaurus)
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