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EBV
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
The herpes virus that causes infectious mononucleosis; associated with specific cancers in Africa and China
Synonyms:
Classified under:
Hypernyms ("EBV" is a kind of...):
herpes; herpes virus (any of the animal viruses that cause painful blisters on the skin)
Context examples:
Allogeneic tri-viral specific, adenovirus, cytomegalovirus and Epstein-Barr virus (Adv, CMV and EBV or ACE), cytotoxic T-lymphocytes (CTLs) with potential antiviral activity.
(Adenovirus/Cytomegalovirus/Epstein-Barr Virus-specific Allogeneic Cytotoxic T Lymphocytes, NCI Thesaurus)
Autologous dendritic cells (DCs) transduced with the replication-deficient adenoviral vector Ad5F53 encoding the Epstein-Barr virus (EBV) transmembrane latent membrane proteins 1 and 2 (LMP1/LMP2) with potential immunostimulatory activity.
(Ad5F35-LMP1/LMP2-Transduced Autologous Dendritic Cells, NCI Thesaurus)
A preparation of allogeneic Epstein-Barr virus (EBV)- and human cytomegalovirus (CMV)-specific CD8+ central memory-derived T effector-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) anti-CD19/CD3 zeta chain fusion protein coupled to the intracellular signal domain of CD28 antigen, with potential immunostimulating, anti-viral and antineoplastic activities.
(Allogeneic CD19-specific CAR-modified CD8 Plus Central Memory-derived Virus-specific T Cells, NCI Thesaurus)
A preparation of transforming growth factor-beta (TGF-beta)-resistant Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTLs) directed to EBV through their native receptor and HER2 through a retrovirally transduced HER2 chimeric antigen receptor (CAR) with potential antineoplastic activity.
(Autologous TGFbeta-Resistant HER2/EBV-Specific Cytotoxic T Lymphocytes, NCI Thesaurus)
Most people acquire EBV in early childhood, experience no symptoms or only a brief, mild cold-like illness, and remain infected throughout their lives while remaining asymptomatic.
(Epstein-Barr virus protein can “switch on” risk genes for autoimmune diseases, National Institutes of Health)
However, the latter term may also apply to lymphomatoid granulomatosis, which is an angiocentric and angiodestructive EBV positive B-cell lymphoproliferative disorder.
(Nasal Type Extranodal NK/T-Cell Lymphoma, NCI Thesaurus)
After an allogeneic hematopoietic stem cell transplant (HSCT), infusion of these CTLs primed towards Adv, CMV and EBV may prevent viral infection by these pathogens.
(Adenovirus/Cytomegalovirus/Epstein-Barr Virus-specific Allogeneic Cytotoxic T Lymphocytes, NCI Thesaurus)
A preparation of allogeneic Epstein-Barr virus (EBV) specific cytotoxic T-lymphocytes (CTL) with potential antineoplastic activity.
(Allogeneic Epstein-Barr Virus-Specific Cytotoxic T-Lymphocytes, NCI Thesaurus)
Peripheral blood mononuclear cells (PBMC) are collected from a donor and are exposed ex vivo to dendritic cells (DCs) transfected with a replication-deficient adenovirus encoding EBV LMP1/2 to generate LMP1/2-specific CTL which are subsequently expanded.
(Allogeneic LMP1/LMP2-Specific Cytotoxic T-Lymphocytes, NCI Thesaurus)
EBV infection is nearly ubiquitous in the human population worldwide.
(Epstein-Barr virus protein can “switch on” risk genes for autoimmune diseases, National Institutes of Health)
