Edotecarin

Pronunciation

Definition 1

A substance being studied in the treatment of cancer. It is a type of topoisomerase I inhibitor. Also called J-107088. (NCI Dictionary)

Definition 2

A synthetic indolocarbazole with antineoplastic activity. Edotecarin inhibits the enzyme topoisomerase I through stabilization of the DNA-enzyme complex and enhanced single-strand DNA cleavage, resulting in inhibition of DNA replication and decreased tumor cell proliferation. (NCI Thesaurus)

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