EF-Hand Domain

Forming a single Ca2+-binding site in many calcium-binding proteins, the basic EF-Hand Domain consists of a conserved 12-residue loop region between two perpendicular 10-12 residue alpha helices (helix-loop-helix). Ca2+ interacts with loop residues in a pentagonal bipyramidal configuration; each loop residue is important for Ca2+ coordination. Loop residues 1, 3, 5, 7, 9, and 12 (invariant Glu or Asp) are directly necessary for Ca2+ binding. Amino-acid variations at positions 1, 3, 5, 7, and 9 alter ion affinity. Single or multiple domains cause structural/functional variations. EF-hand Proteins are grouped into either regulatory/signaling or structural/buffering/transport categories. Ca2+ binding to regulatory proteins induces conformational/functional change; Ca2+ binding to structural proteins seems to provide a Ca2+ buffer. (NCI Thesaurus)

YOU MAY ALSO LIKE

EF-2 Peptide

A synthetic peptide derived from the protein ESW/FLI1 type 2 with potential use in cancer immunotherapy. EWS/FLI1 is a fusion protein frequently…

EF-1 Peptide

A synthetic peptide derived from the protein ESW/FLI1 type 1 with potential use in cancer immunotherapy. EWS/FLI1 is a fusion protein frequently…

EEG biofeedback

A treatment being studied to improve brain function in certain brain disorders and in patients treated with chemotherapy for breast cancer. Sensors…

EEG

A recording of electrical activity in the brain. It is made by placing electrodes on the scalp (the skin covering the top…

EEF2 wt Allele

Human EEF2 wild-type allele is located within 19pter-q12 and is approximately 9 kb in length. This allele, which encodes elongation factor 2…

EEF2 Gene

This gene plays a role in nucleotide binding and protein biosynthesis.