| Health / Medical Topics |
Eflornithine Hydrochloride
The hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. (NCI Thesaurus)
YOU MAY ALSO LIKE
A substance that is being studied in the prevention of cancer. It belongs to the family of drugs called antiprotozoals.
An abnormal collection of fluid in hollow spaces or between tissues of the body. For example, a pleural effusion is a collection…
Physical or mental energy; hard work.
For NDAs, ANDAs, and BLAs, this represents an application to modify the current indications or claims for a use for which the…
A study of the relative therapeutic efficacy of treatment of a disease. Usually this is a Phase II or III study. …
Effectiveness. In medicine, the ability of an intervention (for example, a drug or surgery) to produce the desired beneficial effect.
