EGFR Antisense DNA

A synthetic sequence of DNA constructed in the antisense orientation to a sequence of DNA in epidermal growth factor receptor (EGFR), a member of the erbB gene family. EGFR antisense DNA suppresses the expression of EGFR by tumor cells, thereby inhibiting tumor cell proliferation and decreasing tumor growth. This agent also appears to reduce the invasiveness of certain breast cancer cells. Members of the erbB gene family are overexpressed in many cancers and play roles in carcinogenesis and the regulation of cell proliferation. (NCI Thesaurus)

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EGFR Activating Mutation

A somatic mutation of the epidermal growth factor receptor gene which encodes a 170kDa transmembrane protein, a short transmembrane region, and an…

EGFR

The protein found on the surface of some cells and to which epidermal growth factor binds, causing the cells to divide. It…

EGFL6 wt Allele

Human EGFL6 wild-type allele is located within Xp22 and is approximately 64 kb in length. This allele, which encodes EGF-Like Protein 6,…

EGFL6 Gene

This gene plays a role in cell cycle and may play a role in cell growth.

EGF-Like Domain-Containing Protein 6

EGF-like domain-containing protein 6 (553 aa, 61 kD) is a cell cycle protein that is encoded by the human EGFL6 gene and…

EGF-Like Domain

A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF) has been shown…