EGFR Inhibitor HM61713

An orally available small molecule, mutant-selective inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic activity. EGFR inhibitor HM61713 binds to and inhibits mutant forms of EGFR, thereby leading to cell death of EGFR-expressing tumor cells. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced as compared to non-selective EGFR inhibitors which also inhibit the EGFR wild type form. (NCI Thesaurus)

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EGFR Gene Product

A protein encoded by the EGFR gene.

EGFR Gene Mutation

A change in the nucleotide sequence of the EGFR gene.

EGFR Gene

This gene is involved in the epidermal growth factor signal transduction pathway.