Health / Medical Topics |
EGFR-TKI Resistant Mutation
A molecular genetic abnormality indicating the presence of resistance in the epidermal growth factor receptor-tyrosine kinase inhibitor domain, due to secondary mutations of the EGFR gene. (NCI Thesaurus)
YOU MAY ALSO LIKE
Human EGFR wild-type allele is located within 7p12 and is approximately 188 kb in length. This allele, which encodes epidermal growth factor…
A substance that blocks the activity of a protein called epidermal growth factor receptor (EGFR). EGFR is found on the surface of…
A variation in the amino acid sequence for the epidermal growth factor receptor protein.
An orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with…
An orally available small molecule, mutant-selective inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic activity. EGFR inhibitor HM61713 binds to…
An orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic activity. EGFR inhibitor CO-1686 binds to…