Health / Medical Topics

    Enteric-Coated TRPM8 Agonist D-3263 Hydrochloride

    An enteric-coated orally bioavailable formulation of the hydrochloride salt of a small-molecule agonist for transient receptor potential melastatin member 8 (TRPM8 or Trp-p8) with potential antineoplastic activity. The active ingredient in enteric-coated TRPM8 agonist D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. This agent may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH. TRPM8 is a transmembrane calcium channel protein that is normally expressed in prostate cells and appears to be overexpressed in benign prostatic hyperplasia (BPH) and in prostate cancer. (NCI Thesaurus)




    YOU MAY ALSO LIKE

    A tablet covered with a substance that is designed to delay the release of active and/or inert ingredient(s) until the tablet passes…
    A capsule covered with a substance that is designed to delay the release of active and/or inert ingredient(s) until the capsule passes…
    Having made a record of, set down in permanent form, or formally registered to participate in an activity.
    Administration of a substance by the way of the gastrointestinal tract, usually for systemic action. Drug bioavailability can be affected due to…
    A form of nutrition that is delivered into the digestive system as a liquid. Drinking nutrition beverages or formulas and tubefeeding are…
    An anhydrous formulation of entecavir, a synthetic analog of 2-deoxyguanosine with antiviral activity against hepatitis B virus (HBV). Entecavir is activated…

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact