A World of Knowledge
    Health / Medical Topics

    Epiandrosterone

    A dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property. Epiandrosterone, a potential neurosteroid, appears to bind to the gamma-aminobutyric acid (GABA)/benzodiazepine-receptor complex (GABA-RC), acting as a negative non-competitive modulator of GABA-RC as well as signal through the N-methyl-D-aspartate receptor. In addition this agent inhibits the pentose phosphate pathway (PPP) thereby dilating blood vessels pre-contracted by partial depolarization. Also, epiandrosterone inhibits the synthesis of thromboxane A2 in activated platelets, reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen, increases serum levels of insulin-like growth factor 1 and increases cyclic guanosine monophosphate and nitric oxide synthesis. These effects may improve circulation in the microvasculature. (NCI Thesaurus)




    YOU MAY ALSO LIKE

    Human EPHX1 wild-type allele is located in the vicinity of 1q42.1 and is approximately 35 kb in length. This allele, which encodes…
    This gene is involved in both the activation and detoxification of xenobiotics.
    Ephrin-B2 (333 aa, ~37 kDa) is encoded by the human EFNB2 gene. This protein is involved in cell-cell communication.
    A family of glycosylphosphatidylinositol (GPI)-anchored proteins that are involved in forward and reverse cell-cell signaling through binding to ephrin-A receptors (EPHA). …
    Ephrin type-B receptor 3 (998 aa, ~110 kDa) is encoded by the human EPHB3 gene. This protein plays a role in cell-cell…
    Ephrin type-B receptor 2 (1055 aa, ~117 kDa) is encoded by the human EPHB2 gene. This protein is involved in ephrin-B binding,…

    © 1991-2024 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact