| Health / Medical Topics |
ERK Inhibitor BVD-523
An orally available inhibitor of extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. (NCI Thesaurus)
YOU MAY ALSO LIKE
A drug used to treat advanced basal cell carcinoma that has spread to other parts of the body or has come back…
A country in eastern Africa, bordering the Red Sea, between Sudan and Ethiopia.
The tetrasodium salt of a synthetic analogue of the lipid A portion of the endotoxin lipopolysaccharide (LPS) with potential immunomodulating activity. Eritoran…
An orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Erismodegib selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo,…
A naturally occurring, fibrous mineral consisting of white, prismatic crystals. Erionite is one of the more common types of zeolites that are…
A drug used to treat metastatic breast cancer in patients who have already been treated with other chemotherapy. It is also being…
