Erythrocyte Differentiation Pathway

Stem cells in the bone marrow produce a variety of hematopoietic cell types from common progenitor cells under the influence of cytokines and growth factors. CFU-GEMM cells are a key intermediate in the differentiation of granulocytes, erythrocytes, monocytes and megakaryocytes. Erythropoietin (EPO) is a cytokine produced in the kidneys that, along with other cytokines, induces red blood cell (erythrocyte) differentiation in the bone marrow from CFU-GEMM cells. As the erythrocyte lineage progresses, cells lose their nuclei, and move out of the bone marrow into circulation. The ability of EPO to selectively induce red blood cell differentiation has allowed extensive therapeutic use of the recombinant form of this cytokine to treat anemias. (NCI Thesaurus/BIOCARTA)

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Erythrocyte Differentiation

A biological process that refers to the maturation of erythrocytes.

Erythrocyte Count

The determination of the number of erythrocytes in a blood sample.

Erythrocyte Cell Morphology

An examination or assessment of the form and structure of red blood cells.

Erythrocyte Cell Clumps Measurement

The determination of the amount of erythrocyte cell clumps present in a sample.

Erythrocyte Agglutination Measurement

The determination of the amount of erythrocyte agglutination present in a sample.

Erythrocyte

A type of blood cell that is made in the bone marrow and found in the blood. Erythrocytes contain a protein called…