| Health / Medical Topics |
ETS Family Gene
The Ets family of transcription factors includes nuclear phosphoproteins that are involved in cell proliferation, differentiation and oncogenic transformation. The family is defined by a conserved DNA-binding domain (the ETS-DBD), which forms a highly conserved, winged, helix-turn-helix structural motif. As targets of the Ras-MAPK signaling pathway, Ets proteins function as critical nuclear integrators of ubiquitous signaling cascades. To direct signals to specific target genes, ETS proteins interact with other transcription factors that determine the binding specificity of ETS proteins to RAS-response elements in target genes. (NCI Thesaurus)
YOU MAY ALSO LIKE
ETS domain-containing transcription factor ERF (548 aa, ~59 kDa) is encoded by the human ERF gene. This protein is involved in the…
ETS domain-containing protein Elk-4 (431 aa, ~47 kDa) is encoded by the human ELK4 gene. This protein is involved in transcriptional…
ETS domain-containing protein Elk-3 (407 aa, ~44 kDa) is encoded by the human ELK3 gene. This protein plays a role in signal…
ETS domain-containing protein Elk-1 (428 aa, ~45 kDa) is encoded by the human ELK1 gene. This protein is involved in the positive…
Usually C-terminal, the conserved ETS (Erythroblast Transformation Specific) Domain of 85-90 amino acids, rich in positively-charged and aromatic residues, binds to purine-rich…
Smoke that comes from the burning of a tobacco product and smoke that is exhaled by smokers. Inhaling ETS is called involuntary…
