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ETV6/ACSL6 Fusion Gene
A fusion gene that results from a chromosomal translocation t(5;12)(q31;p13) which fuses exon 1 of the ETV6 gene out-of-frame to either exon 1 or exon 11 or to the 3' untranslated region of the ACSL6 gene. This rearrangement was observed in one patient with refractory anemia with excess blasts with basophilia, one patient with acute myelogenous leukemia with eosinophilia, and one patient with acute eosinophilic leukemia (NCI Thesaurus)
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A fusion protein encoded by the ETV6/ABL2 fusion gene. This protein is comprised of the N-terminal half of the transcription factor ETV6…
A fusion gene that results from a chromosomal translocation t(1;12)(q25;p13) which fuses exon 5 of the ETV6 gene to a site within…
Expression of the ETV6-PDGFRB fusion transcript resulting from the rearrangement of the PDGFRB gene.
Human ETV6 wild-type allele is located in the vicinity of 12p13 and is approximately 246 kb in length. This allele, which encodes…
A molecular genetic abnormality that refers to the presence of a mutation in the ETV6 gene (ETS variant gene 6).
This gene plays a regulatory role in transcription and in matrix metalloproteinase activity.
