Health / Medical Topics |
EWSR1/PATZ1 Fusion Protein Long B Isoform
A fusion protein (609 aa, ~66 kDa) encoded by the EWSR1/PATZ1 fusion gene long B isoform. This protein is comprised of the transactivation domain of the RNA-binding protein EWS fused to the C-terminus of POZ-, AT hook-, and zinc finger-containing protein 1 containing two C2H2 zinc-finger DNA binding domains. (NCI Thesaurus)
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A fusion gene that results from a chromosomal inversion inv(22)(q12q12) which fuses the first eight exons of the EWSR1 gene with the…