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EXCITATORY
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
(of drugs e.g.) able to excite or stimulate
Synonyms:
excitant; excitative; excitatory
Classified under:
Similar:
stimulative (capable of arousing or accelerating physiological or psychological activity or response by a chemical agent)
Derivation:
excite (act as a stimulant)
excite (raise to a higher energy level)
Context examples:
It acts at spinal and supraspinal sites, reducing excitatory transmission.
(Baclofen, NCI Thesaurus)
This allele, which encodes glutamate receptor 3 protein, is involved in the modulation of excitatory neurotransmission.
(GRIA3 wt Allele, NCI Thesaurus)
In contrast, this agent also acts as a co-agonist, along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
(Glycine, NCI Thesaurus)
Enflurane may also inhibit glutamatergic excitatory transmission.
(Enflurane, NCI Thesaurus)
Physiological effects include an increase in motor activity, euphoria, increased mental alertness, excitatory behavior, and appetite suppression.
(Amphetamine Aspartate, NCI Thesaurus)
They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
(Neuroprotective Agent, NLM, Medical Subject Headings)
A topical preparation containing the antidepressant amitriptyline and the excitatory amino acid antagonist ketamine with potential topical analgesic activity.
(Ketamine/Amitriptyline NP-H Cream, NCI Thesaurus)
In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates.
(Bumetanide, NCI Thesaurus)
Gamma-aminobutyric acid (GABA), converted from the principal excitatory neurotransmitter glutamate in the brain, plays a role in regulating neuronal excitability by binding to its receptors, GABA-A and GABA-B, and thereby causing ion channel opening, hyperpolarization and eventually inhibition of neurotransmission.
(Gamma-Aminobutyric Acid, NCI Thesaurus)
In addition, D-cycloserine is an excitatory amino acid and partial agonist at the glycine binding site of the NMDA receptor in the central nervous system (CNS); binding to the central NMDA receptor may result in amelioration of neuropathic pain.
(Cycloserine, NCI Thesaurus)
