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EXOTOXIN
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I. (noun)
Sense 1
Meaning:
A toxin that is secreted by microorganisms into the surrounding medium
Classified under:
Hypernyms ("exotoxin" is a kind of...):
toxin (a poisonous substance produced during the metabolism and growth of certain microorganisms and some higher plant and animal species)
Antonym:
endotoxin (a toxin that is confined inside the microorganisms and is released only when the microorganisms are broken down or die)
Context examples:
A fusion protein immunotoxin consisting of a humanized, single-chain monoclonal antibody fragment specific for the epithelial cell adhesion molecule (EpCAM) conjugated with a truncated form of Pseudomonas exotoxin A with potential antineoplastic activity.
(Anti-EpCAM Antibody Fragment-Pseudomonas-exotoxin Fusion Protein, NCI Thesaurus)
Pseudomonas exotoxin PE38KDEL was modified to remove the natural cell binding domain.
(Anti-EGFRvIII Immunotoxin MR1-1, NCI Thesaurus)
A recombinant monoclonal antibody (OVB3) directed against human ovarian cancer linked with an exotoxin derived from the bacterium Pseudomonas aeruginosa.
(Monoclonal Antibody OVB3-PE, NCI Thesaurus)
A single-chain immunotoxin consisting of Fv fragments of the BR96 monoclonal antibody (MoAb) and a truncated Pseudomonas exotoxin (PE40) that lacking the binding domain.
(BR96 sFv-PE40, NCI Thesaurus)
This bacteria is catalase and oxidase negative, ferments lactose, produces the exotoxin Pyolysin O and neuraminidases and is hemolytic.
(Arcanobacterium pyogenes, NCI Thesaurus)
Anti-EpCAM-Pseudomonas-exotoxin fusion protein is made by linking a monoclonal antibody fragment to a toxic protein that may kill cancer cells.
(Anti-EpCAM Antibody Fragment-Pseudomonas-exotoxin Fusion Protein, NCI Dictionary)
An immunotoxin consisting of a monoclonal antibody directed against epithelial glycoprotein-2 (EP-2, or epithelial cell adhesion molecule (EpCAM)) conjugated to the bacterial toxin Pseudomonas exotoxin A (PE) with potential antineoplastic activity.
(Anti-EGP-2 Immunotoxin MOC31-PE, NCI Thesaurus)
Cintredekin besudotox is composed of interleukin-13 (IL13), a pleiotropic immunoregulatory cytokine, linked to a mutated form of pseudomonas exotoxin A; this agent targets and kills tumor cells that express the IL13 receptor (IL13R).The IL13 moiety attaches to the IL13R on the tumor cell membrane, facilitating the entry of the exotoxin.
(Cintredekin Besudotox, NCI Thesaurus)
The dose of a chemical or biologic preparation (e.g., a bacterial exotoxin or a suspension of bacteria) that is likely to cause death in 50% of the animals being tested; it varies in relation to the type of animal and the route of administration; (the absolute lethal dose is LD100, and minimal lethal dose is LD05).
(LD-50, NCI Thesaurus)
The antibody attaches to the IL-2R on the cell membrane, facilitating the entry of the exotoxin.
(LMB-2 immunotoxin, NCI Thesaurus)
