Extraosseous Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Definition 1

A spectrum of malignant tumors arising from the soft tissues, characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. Pain and the presence of a mass are the most common clinical symptoms. (NCI Thesaurus)

Definition 2

Round cell sarcomas of soft tissue with varying degrees of neuroectodermal differentiation. There is a recurrent cytogenetic aberration, most commonly t(11;22)(q24;q12) and t(21;22)(q22;q12). (NCI Thesaurus)

YOU MAY ALSO LIKE

Extraosseous Ewing Sarcoma

A rare malignant neoplasm of the soft tissues. It is typically a disease of children and young adults. It is…

Extraosseous

Located outside of the bone.

Extraordinary Opportunity: Research on Tobacco and Tobacco Related Cancers

Goal : to expand our understanding of tobacco addiction and the biological mechanisms underlying tobacco-induced cancers, develop ways to keep people of…

Extraordinary Opportunity: Preclinical Models of Cancer

Goal: refine current models, create models that more closely parallel human cancers, devise efficient procedures that will make models available to all…

Extraordinary Opportunity: Molecular Targets of Prevention and Treatment

Goal: we now have very focused targets against which to direct prevention and therapy efforts. The Molecular Targets Initiative will seek to…

Extraordinary Opportunity: Imaging Technologies

Goal: to develop a comprehensive imaging research program to fit the development of imaging technology with medical needs to create a system…