FAK Inhibitor GSK2256098

A focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor GSK2256098 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thereby inhibiting tumor cell migration, proliferation and survival, and tumor angiogenesis. The tyrosine kinase FAK is normally activated by binding to integrins in the extracellular matrix (ECM) but may be upregulated and constitutively activated in various tumor cell types. (NCI Thesaurus)

YOU MAY ALSO LIKE

FAK Family Tyrosine Kinase

Soluble cytoplasmic non-receptor FAK (Focal Adhesion Kinase) Family Tyrosine Kinases catalyze the phosphorylation of tyrosine residues in proteins with ATP or other…

Fairly Often

A subjective answer that something occurs relatively frequently.

FAIRE-Seq

A molecular genetic technique that depletes a biological sample of nucleosomal DNA and then subjects the non-nucleosome-associated DNA to next-generation sequencing. Since…

Fair

Having no exceptional quality or ability.

Fainting

Extremely weak; threatened with syncope.

Failure to Unwrap Medical Device Problem

Issue associated with problems removing the materials used to construct the cover or outer wrapping of the device.