| Health / Medical Topics |
FGFR Substrate 3
Encoded by human FRS3 Gene, 492-aa 54-kDa plasma membrane-associated FGFR Substrate 3 is an FGFR substrate that links FGFR stimulation to RAS activators. Similar (49% identical) to FRS2, FRS3 also contains a myristylation sequence, a PTB domain, and Tyr-containing motifs that govern GRB2 and SHP2 recruitment. FRS2 and FRS3 bind directly to FGFR1; an FGFR1 juxtamembrane segment and the PTB domain appear to interact and mediate FRS Tyr phosphorylation. (NCI Thesaurus)
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