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FIBRINOGEN
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A protein present in blood plasma; converts to fibrin when blood clots
Synonyms:
factor I; fibrinogen
Classified under:
Hypernyms ("fibrinogen" is a kind of...):
clotting factor; coagulation factor (any of the factors in the blood whose actions are essential for blood coagulation)
Context examples:
Blood coagulation is another series of proenzyme-to-serine protease conversions, culminating the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot.
(Complement and Coagulation Cascade, NCI Thesaurus/KEGG)
The third stage is clot formation as a result of fibrinogen cleavage by activated thrombin.
(Extrinsic Prothrombin Activation Pathway, NCI Thesaurus/BIOCARTA)
Upon administration, ancrod cleaves fibrinogen and releases A-fibrinopeptides.
(Ancrod, NCI Thesaurus)
In turn, factor Xa/Va complex activates thrombin, which cleaves fibrinogen into fibrin, eventually resulting in blood clot formation.
(Antihemophilic Factor, Human Recombinant, NCI Thesaurus)
Orthologous to human thrombin, batroxobin activates soluble fibrinogen into fibrin and facilitates blood coagulation, thereby can be used in substitution of thrombin in quantitative thrombin time test.
(Batroxobin, NCI Thesaurus)
A unit of measure for the concentration of fibrin degradation products in a sample, calculated based upon the mass of fibrinogen contained within that sample.
(Fibrinogen Equivalent Unit, NCI Thesaurus)
A blood coagulation disorder characterized by the complete absence of fibrinogen in the blood, resulting in bleeding.
(Afibrinogenemia, NCI Thesaurus)
Increased cellular Ca2+ facilitates binding of fibrinogen.
(Acute Myocardial Infarction Pathway, NCI Thesaurus/BIOCARTA)
In activated platelets, these three signaling pathways are downstream of integrin activation mediated by collagen binding and influence the association of fibrinogen with its receptors.
(Andrographolide, NCI Thesaurus)
Abciximab binds to the GP IIb/IIIa receptor on the platelet membrane, which inhibits the binding of fibrinogen to the GP IIb/IIIa receptor.
(Abciximab, NCI Thesaurus)
