| Health / Medical Topics |
Fibroblast Growth Factor 1
A modifier of endothelial cell migration and proliferation, Fibroblast Growth Factor 1 may be important in neovascularization. Acidic Fibroblast Growth Factor and alpha-ECGF are derived from FGF1 by posttranslational processing. FGF1 causes the foregut endoderm to develop into the liver. The hepatogenic response is restricted to endoderm tissue, which selectively co-expresses FGF receptors 1 and 4. Different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis. FGF1 binding to FGFR2 is accompanied by binding of a heparin decasaccharide. (from OMIM 131220 and NCI) (NCI Thesaurus)
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