Fibroblast Growth Factor Receptor 2

KGF is a potent mitogenic paracrine mediator of epithelial cell proliferation. The keratinocyte growth factor receptor is a FGFR RTK family member with three extracellular Ig-like domains, a single membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. Two alternatively spliced FGFR2 gene products, KGFR and BEK, vary in sequence within the third extracellular Ig loop, which influence ligand-binding characteristics. Control of these alternative splice sites is thought to involve transacting factors. These receptors also have different patterns of expression. KGFR appears to have a role in skin development; BEK is preferentially expressed in osteogenesis. Dimerization of the FGFR2 ectodomain is induced by binding to FGF1 and a heparin decasaccharide, essential in FGF signaling. (from OMIM 176943 and NCI) (NCI Thesaurus)

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